958 Encapsulating Peritoneal Sclerosis with Pericardial Tamponade: A Case Report

Abstract Aim Encapsulating peritoneal sclerosis (EPS) is a rare morbidity associated primarily with dialysis. Definitive diagnosis and management can often be prolonged complicated. The pathogenesis two-hit hypothesis of inflammation myofibroblast differentiation. This report aims to demonstrate the EPS provide insight into management. Method We present unique case patient who follows ‘classical’ disease course before developing concomitant pericardial sclerosis, presenting cardiac tamponade. explore proposed pathophysiology for both uncommon pathologies in same patient. Results A 45-year-old male was treated went on develop sclerosis. Following referral our centre, underwent semi-elective surgical enterolysis peritonectomy EPS, excision all sclerotic obstructing membrane. Two weeks following surgery, he developed tamponade cardiovascular compromise, unresolved by two separate episodes pericardiocentesis, leading intervention. pleural window created via open thoracotomy 800ml thick clotted blood removed from cavity. Histology demonstrated Conclusions given Uraemia may common mediator peritoneum pericardium, predisposing membranes identical embryological origin. Pericardial patients but not manifest itself clinically large. It also demonstrates that effective intervention lead excellent outcomes.